Okulungileyo kumathumbu kubantu abadala kunokuba luncedo nakwingqondo zabo. Uphononongo oluphambili oluvela kwisibini lufumanise ukuba iproteni yemihla ngemihla kunye ne-prebiotic supplementation ziphucula ukusebenza kwememori kubantu abangaphezu kwama-60.
Iziphumo zolu phando, ezapapashwa ekuqaleni konyaka ophelileyo, zivuselela ingcinga, ingakumbi xa ucinga ukuba inkumbulo efanayo yokubona kunye novavanyo lokufunda ziye zasetyenziswa ukufumanisa iimpawu zokuqala zesifo sika-Alzheimer.
Olu phononongo olungaboniyo lubandakanya ii-prebiotics ezimbini ezingabizi kakhulu, ezisekelwe kwizityalo ezifumaneka kwiikhemesti kwihlabathi liphela.
Iiprebiotics zizinto ezingagayekiyo ezinceda ekuvuseleleni i-microflora yamathumbu. Olunye uhlobo lwesongezo yi-inulin, ifayibha yokutya esekwe kwi-fructan. Olunye yi-fructooligosaccharides (FOS), iicarbohydrate ezisekwe kwizityalo ezisetyenziswa njengeswiti yendalo enekhalori eziphantsi.
Ukuze kuvavanywe imiphumo yezi zongezo kwingqondo ekhulileyo, abaphandi baseKing's College eLondon baqeshe amawele angama-36 aneminyaka engama-60 nangaphezulu.
Isibini ngasinye samawele sahlulwe ngokungacwangciswanga saba ngamaqela amabini: elinye iqela lathatha umgubo weproteni oqulethe ii-prebiotics imihla ngemihla, kwaye elinye iqela lathatha umgubo weproteni oqulethe i-placebo imihla ngemihla.
Emva kweenyanga ezintathu, kwiimvavanyo zengqondo, amawele awayengazi ukuba i-inulin okanye i-fructooligosaccharide isetyenziswa kangakanani asebenza ngcono.
Ngaphezu koko, ukutya ifayibha yokutya imihla ngemihla kwakunxulunyaniswa notshintsho oluncinci kwi-microbiota yamathumbu amawele. Umzekelo, amawele asebenzisa i-inulin okanye i-fructooligosaccharides ayenenani eliphezulu le-bifidobacteria eluncedo.
Izifundo eziqhutywe kwiimpuku zibonise ukuba i-bifidobacteria inokunciphisa ukuphazamiseka kwengqondo ngokuguqula unxibelelwano phakathi kwamathumbu nengqondo.
“Siyavuya ukubona olu tshintsho kwiiveki ezili-12 kuphela. Oku kunefuthe elikhulu ekuphuculeni impilo yengqondo kunye nenkumbulo kubantu abadala,” utshilo uMary N. Lockley, umphandi wezifo zabantu abadala kwiKing's College eLondon, xa iziphumo zophando zapapashwa ngoMatshi 2024.
"Ukuvula iimfihlo ze-axis yobuchopho-ngaphakathi kunokunceda abantu baphile ubomi obusempilweni nobude."
IKholeji yaseKing's ineyona rejistri inkulu yamawele amadala e-UK, kwaye izifundo zamawele zibalulekile ekuqondeni impembelelo yemfuza kunye nokusingqongileyo kwimpilo yabantu.
Izifundo zangaphambili kwiimpuku zibonise ukuba izongezo ezinefayibha ephezulu ezifana ne-inulin kunye ne-fructooligosaccharides zinokondla i-colonic microbiota, zivumele iintsholongwane "ezilungileyo" ukuba zikhule.
Iibhaktheriya ezithile zidibene nokusebenza kakuhle kwengqondo kwiimpuku nakubantu.
Ubungqina obukhulayo bubonisa unxibelelwano olusondeleyo phakathi kwamathumbu nengqondo. Ezinye iingcali ngoku ziyaqiniseka ngezi ziphumo, zide zibize amathumbu ngokuthi “ubuchopho besibini” bomzimba.
Uphando lwakutshanje olwenziwe kumawele olwenziwe kwiKing's College eLondon lubonisa ukuba ukutya ukutya okuthile “okukhuthaza ubuchopho” kunokuba yindlela ethembisayo yokunyanga ukuphazamiseka kwengqondo.
Nangona ii-prebiotics zinokuphucula ezinye iinkalo zomsebenzi wokuqonda kubantu abadala, ezifana nenkumbulo kunye nesantya sokucubungula, akubonakali ngathi kukho iingenelo ezibalulekileyo zomzimba.
Nangona i-inulin kunye ne-fructooligosaccharides zizinto ezibalulekileyo zokugcina impilo yemisipha, ukulahleka kwemisipha akuzange kuphucuke kumawele amadala athathe izongezo ezinefayibha eninzi.
“Ezi fibre zezityalo ezingabizi kakhulu, ezithengiswa ngaphandle kwemvume kagqirha zinganceda abantu abaninzi ngeli xesha lobunzima kwezoqoqosho. Zikhuselekile kwaye zifumaneka lula,” utshilo uClaire Stevens, ingcali kwezonyango lwabantu abadala eKing's College eLondon.
"Umsebenzi wethu olandelayo kukubona ukuba ezi ziphumo zingagcinwa na ixesha elide nakwinani elikhulu labantu."
Uninzi lwamawele kolu phononongo yayingamabhinqa. Nangona abaphandi belungise iziphumo ukuze bajonge umahluko phakathi kwesini, bavumile nokuba kukho ukukhetha okukhethiweyo okusenokuba kukho kwiqela lamawele e-KCL.
Ngamanye amazwi, abafazi banamathuba amaninzi okufumana isifo se-Alzheimer, kwaye izifundo ezifana nezi zixhasa umbono omtsha wokuba ukuwohloka kwengqondo akusoloko kubangelwa sisifo sengqondo kwaye kunokunxulunyaniswa nezinto zangaphandle.
Amathumbu anxulumene kakhulu neenkqubo ezininzi zomzimba, kuquka iinkqubo zomzimba zokuzikhusela kunye nezemithambo-luvo. Ukongeza i-gut microbiota ngee-prebiotics ezithile kunye neeprobiotics kunokubangela indlela yokunyanga izifo ezahlukeneyo.
Ixesha leposi: Disemba-31-2025